Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

What is CIDP?

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a rare, long-term neurological disorder. It affects the peripheral nerves—the nerves outside the brain and spinal cord—that help control your muscles and sensations like touch and temperature.

CIDP is considered an autoimmune condition, which means the body’s immune system mistakenly attacks healthy tissue. In CIDP, the immune system damages the myelin sheath, the protective covering around the nerves. This slows down or blocks signals between the brain and the rest of the body.

Symptoms of CIDP

CIDP often develops slowly over several weeks or months. Symptoms may include:

Tingling or numbness in the arms, legs, hands, or feet
Weakness, usually starting in the legs and progressing upward
Difficulty walking, climbing stairs, or lifting objects
Fatigue or general tiredness
Poor balance or coordination
Poor balance or coordination
Loss of reflexes

In some cases, symptoms can worsen over time. Others may experience periods of improvement followed by relapses.

Who Gets CIDP?

CIDP can affect people of any age, but it is more commonly diagnosed in adults, particularly men over the age of 50. It is considered a rare disorder, affecting an estimated 1 to 8 people per 100,000 each year.

What Causes CIDP?

The exact cause is unknown. It is believed to be an autoimmune reaction, possibly triggered by an infection or another condition. Some cases are linked to other autoimmune or inflammatory diseases.

How is CIDP Diagnosed?

Diagnosis can be complex. It often involves:

A physical and neurological exam
Blood tests to rule out other causes
Nerve conduction studies and electromyography (EMG) to check nerve function
Lumbar puncture (spinal tap) to test for abnormal proteins in the spinal fluid
MRI of the spine or nerves

Because CIDP can mimic other neurological disorders, getting an accurate diagnosis is critical.

Is CIDP Treatable?

Yes. While CIDP is chronic, it is often treatable—especially when caught early. Common treatments include:

Immunoglobulin therapy (IVIG or SCIG): Infusions of antibodies to calm the immune response
Corticosteroids: To reduce inflammation
Plasmapheresis (plasma exchange): Removes harmful antibodies from the blood
Immunosuppressive drugs: To further control the immune system

Treatment helps many people regain strength and manage symptoms. Some may achieve long-term remission.

Why Are We Studying CIDP?

Although treatment exists, not all patients respond in the same way. New therapies may offer better, longer-lasting results with fewer side effects. That’s why clinical research—like the study we’re offering—is so important.

By participating, you can:

Next Steps

If you or someone you love is living with CIDP—or suspects they may have it—you may qualify for our clinical trial. Our team will carefully explain the study, evaluate your eligibility, and answer any questions you may have.